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Adverse Drug Events: H Mono/Poly DR-TB Regimen
Learning ObjectivesAdverse Drug Events: H Mono/Poly DR-TB Regimen
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The potential adverse drug events that can occur when using drugs in the H mono/ poly DR-TB regimen are tabulated below:
| ADVERSE DRUG EVENTS | SUSPECTED DRUG(S) |
|---|---|
| Hepatitis | Rifampicin (R), Pyrazinamide (Z) |
| QT prolongation | Fluoroquinolone (FQ), Clofazimine (Cfz) |
| Rash, allergic reaction and anaphylaxis | Any drug |
| Gastrointestinal symptoms | Z, Ethambutol (E), Cfz, FQs |
| Giddiness | FQ, Z |
| Arthralgia | Z, FQ |
| Peripheral neuropathy | FQ, E |
| Depression | FQ |
| Psychotic symptoms | FQ |
| Seizures | FQ |
| Tendonitis and tendon rupture | FQ |
| Vestibular toxicity (tinnitus and dizziness) | FQ |
| Optic neuritis | E, Linezolid (Lzd), Cfz |
| Metallic taste | FQ |
| Superficial fungal infection and thrush | FQ |
Resources
- Guidelines for Programmatic Management of Drug Resistant Tuberculosis in India, March 2021.
- WHO Consolidated Guidelines on Tuberculosis: Module 4 - Treatment: Drug resistant TB Treatment, 2020.
- Technical and Operational Guidelines for TB in India, 2016.
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